Scientific Resources

Explore our collection of peer-reviewed studies, research papers, and technical whitepapers on cognitive-motor integration and brain health assessment.

Research

& Publications

Research Paper
Machine learning algorithms for detection of visuomotor neural control differences in individuals with PASC and ME
This study uses EEG data and machine learning to identify brain function differences in long COVID and ME patients.
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Research Paper
Cognitive-motor integration deficits in young adult athletes following concussion
Assessment of visually guided motor task performance requiring transformation of visual input into motor outputs.
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Research Paper
Sabotage Detection Using DL Models on EEG Data From a Cognitive-Motor Integration Task
AI detects intentional underperformance in cognitive tasks using EEG brain signals with high accuracy.
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Research Paper
Development of rule-based eye-hand-decoupling in children and adolescents
Eye–hand coordination that requires rule-based control develops mainly in late childhood, improving significantly during early adolescence.
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Research Paper
Prolonged cognitive–motor impairments in children and adolescents with a history of concussion
Children with past concussions show lasting cognitive–motor deficits that standard return-to-play tests may miss.
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Research Paper
Motor Deficits in Youth with Concussion History: Issues with Task Novelty or Task Demand?
Youth with concussion history struggle to quickly adapt to complex eye–hand coordination tasks, especially under new task demands.
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Research Paper
Assessment of a Cognitive-Motor Training Program in Adults at Risk for Developing Dementia
Cognitive–motor training strengthens brain networks and improves coordination in adults at risk of dementia.
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Research Paper
Sport experience is correlated with complex motor skill recovery in youth following concussion
Greater sports experience helps youth recover cognitive–motor skills faster after concussion, suggesting a protective “motor reserve” effect.
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Research Paper
Thinking-While-Moving Exercises May Improve Cognition in Elderly with Mild Cognitive Deficits: A Proof-of-Principle Study
Cognitive–motor training improves thinking ability and visuomotor skills in older adults, especially those with mild cognitive deficits.
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Research Paper
Remote concussion history does not affect visually-guided reaching in young adult females
Young adult females with past concussions show no long-term visuomotor deficits under controlled task conditions.
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Research Paper
Preliminary sex differences in human cortical BOLD fMRI activity during the preparation of increasingly complex visually guided movements
Males and females show different brain activation patterns during visuomotor tasks despite similar performance.
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Research Paper
The behavioural consequences of dissociating the spatial directions of eye and arm movements
Forcing eye and arm movements in different directions disrupts typical movement patterns, revealing the brain’s default coupling of gaze and reach.
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Research Paper
Move faster, think later: Women who play action video games have quicker visually- guided responses with later onset visuomotor-related brain activity
Female action video game players show more efficient brain activity and faster visuomotor responses, especially in tasks requiring eye–hand dissociation.
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Research Paper
Looking up while reaching out: the neural correlates of making eye and arm movements in different spatial planes
Visuomotor tasks that dissociate gaze and hand movements engage widespread brain regions more strongly than standard reaching, reflecting sensorimotor recalibration.
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Research Paper
Brain mechanisms for preparing increasingly complex sensory to motor transformations
Nonstandard sensorimotor tasks engage a distributed brain network, including motor and parietal regions, with activity patterns varying by task complexity.
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Research Paper
Evidence for distinct brain networks in the control of rule-based motor behavior
Decoupled reaching relies on distinct neural networks, with explicit rule-based control and sensorimotor recalibration supporting different movement strategies.
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Research Paper
Extensive video-game experience alters cortical networks for complex visuomotor transformations
Extensive video-game experience enhances prefrontal and visuomotor network activity, improving planning for complex eye–hand coordination tasks.
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Research Paper
The Role of the Caudal Superior Parietal Lobule in Updating Hand Location in Peripheral Vision: Further Evidence from Optic Ataxia
Patients with optic ataxia rely on additional eye movements to compensate for peripheral visuomotor deficits, highlighting the caudal superior parietal lobule’s role in updating hand position.
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Research Paper
Decoupled Visually-Guided Reaching in Optic Ataxia: Differences in Motor Control between Canonical and Non- Canonical Orientations in Space
Bilateral superior parietal damage impairs decoupled visuomotor control, especially for non-canonical targets requiring sensorimotor recalibration.
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Research Paper
Parietal Area 5 Activity Does Not Reflect the Differential Time-Course of Motor Output Kinetics During Arm-Reaching and Isometric-Force Tasks
Neurons in parietal area 5 are less sensitive than M1 neurons to the timing and direction of forces during reaching and isometric tasks.
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Research Paper
Visuomotor Impairments in Older Adults at Increased Alzheimer’s Disease Risk
Kinematic measures of complex visuomotor tasks detect early impairments in adults at risk for Alzheimer’s disease with high accuracy.
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Research Paper
Move faster, think later: Women who play action video games have quicker visually- guided responses with later onset visuomotor-related brain activity
Female action video game players show more efficient brain activity and faster visuomotor responses, especially in tasks requiring eye–hand dissociation.
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Research Paper
Looking up while reaching out: the neural correlates of making eye and arm movements in different spatial planes
Visuomotor tasks that dissociate gaze and hand movements engage widespread brain regions more strongly than standard reaching, reflecting sensorimotor recalibration.
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Research Paper
Brain mechanisms for preparing increasingly complex sensory to motor transformations
Nonstandard sensorimotor tasks engage a distributed brain network, including motor and parietal regions, with activity patterns varying by task complexity.
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Research Paper
Adults at Increased Alzheimer’s Disease Risk Display Cognitive-Motor Integration Impairment Associated with Changes in Resting-State Functional Connectivity: A Preliminary Study
Poorer cognitive–motor integration in adults at risk for Alzheimer’s disease is linked to reduced resting-state brain connectivity.
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Research Paper
Neural Activity in Superior Parietal Cortex during Rule-based Visual-motor Transformations
The superior parietal lobule encodes rule-based information to transform nonstandard sensory inputs into accurate motor actions.
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Research Paper
Diffusion Tensor Imaging Correlates of Cognitive-Motor Decline in Normal Aging and Increased Alzheimer’s Disease Risk
White matter deterioration in adults at risk for Alzheimer’s disease is linked to impaired cognitive–motor control, suggesting a potential early detection marker.
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Research Paper
Comparison of baseline and postconcussion SCAT3 scores and symptoms in varsity athletes: an investigation into differences by sex and history of concussion
In varsity athletes, SCAT3 primarily detects self-reported symptoms after concussion, with limited utility for other measures or differences by sex and concussion history.
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Research Paper
White Matter Integrity and Its Relationship to Cognitive-Motor Integration in Females with and without Post-Concussion Syndrome
White matter integrity correlates with cognitive–motor integration performance, even when individuals with post-concussion syndrome show no overt deficits.
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Research Paper
Cortical and cerebellar structural correlates of cognitive-motor integration performance in females with and without persistent concussion symptoms
Structural differences in the frontoparietal-cerebellar network relate to cognitive–motor integration, suggesting compensatory mechanisms in individuals with post-concussion syndrome.
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Research Paper
Concussion can increase the risk of visually induced motion sickness
Symptomatic individuals with concussion are more sensitive to visually induced motion sickness, highlighting considerations for VR-based assessment and rehabilitation.
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Research Paper
Prefrontal cortex activity during virtual obstacle avoidance and distracted walking: A methodological proof of concept using augmented reality and functional near-infrared spectroscopy
A novel fNIRS and AR protocol uses virtual obstacles to study how attention affects prefrontal activity and gait during dual-task walking.
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Research Paper
Hand placement near the visual stimulus improves orientation selectivity in V2 neurons
Hand proximity enhances visual processing in V2 neurons, sharpening orientation selectivity and supporting optimized motor control.
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Research Paper
Cognitive-Motor Integration Performance Is 2 Affected by Sex, APOE Status, and Family 3 History of Dementia
Sex and genetic risk factors influence cognitive–motor integration, with at-risk females and APOE4 carriers showing poorer performance on complex visuomotor tasks.
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Research Paper
Differences in resting state functional connectivity underlie visuomotor performance declines in older adults with a genetic risk (APOE ε4) for Alzheimer’s disease
APOE ε4 carriers show altered resting-state connectivity in the default and dorsal attention networks, predicting poorer non-standard visuomotor performance.
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Research Paper
Differences in structural MRI and diffusion tensor imaging underlie visuomotor performance declines in older adults with an increased risk for Alzheimer’s disease
In APOE ε4 carriers, reduced grey matter in medial temporal regions and lower white matter integrity in key tracts predict poorer non-standard visuomotor performance.
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Research Paper
Sex differences in the neural underpinnings of unimanual and bimanual control in adults
Sex differences in brain connectivity underlie bimanual coordination, with women showing greater interhemispheric cortical connectivity and men showing stronger cerebellar connectivity.ces by sex and concussion history.
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Research Paper
Beyond sex: the effects of testosterone on visuomotor performance in men and women
Testosterone levels predict cognitive-motor integration performance, linked to structural differences in visuomotor brain regions.
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Research Paper
Differences in spectral profiles between rostral and caudal premotor cortex when hand-eye actions are decoupled
Rostral PMd integrates rule-based aspects of decoupled reaches, while caudal PMd updates movements online during eye-hand dissociation.
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Research Paper
Decoupling the actions of the eyes from the hand alters beta and gamma synchrony within SPL
Decoupled eye-hand movements alter SPL beta and gamma synchrony during planning and execution.
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Research Paper
Sex‑related differences in visuomotor skill recovery following concussion in working‑aged adults
Concussion impairs cognitive-motor integration, but visuomotor skill improves with recovery, especially in females, highlighting sex-related differences in skilled performance networks.
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Research Paper
The Contribution of Different Cortical Regions to the Control of Spatially Decoupled Eye–Hand Coordination
Spike–field coherence in PMd and SPL varies with eye–hand coupling, revealing distinct cortical control patterns for decoupled versus coupled reaches.
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Research Paper
Systematic Changes in Motor Cortex Cell Activity With Arm Posture During Directional Isometric Force Generation
Motor cortex neurons systematically adjust directional tuning and activity with hand posture during isometric force generation, reflecting transformations between extrinsic and intrinsic motor representations.
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Research Paper
The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance
Blast and impact-related mild traumatic brain injuries impair cognitive-motor integration, affecting rule-based skilled performance, with effects modulated by age, sex, and expertise.
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Research Paper
Motor Cortex Neural Correlates of Output Kinematics and Kinetics During
Isometric-Force and Arm-Reaching TasksMotor Cortex Neural Correlates of Output Kinematics and Kinetics During Isometric-Force and Arm-Reaching Tasks
Caudal M1 neurons encode task-specific arm movement dynamics, dissociating neural activity from hand motion in reaching versus isometric tasks.
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Research Paper
Visuomotor integration is impaired in early stage Alzheimer's disease
Alzheimer’s patients show marked deficits in visuomotor transformations, with slower, less accurate movements and greater errors even with minimal cognitive impairment.
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Research Paper
Development of a novel cognitive-motor integration balance assessment in healthy young adults: a pilot study
This pilot study compares full-body and upper extremity cognitive-motor integration tasks, finding greater difficulty in full-body tasks and performance influences from age, sex, and sport experience.
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Research Paper
Visuomotor Integration Is Compromised in Alzheimer’s Disease Patients Reaching for Remembered Targets
Alzheimer’s patients show early deficits in integrating visual information for accurate motor responses.
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Research Paper
Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation
rTMS of human PPC reveals that SPOC encodes retinally peripheral reach goals, while mIPS and AG overlap in saccade and reach planning, with motor details specific to hand movements.
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Research Paper
Compromised visually guided motor control in individuals with Alzheimer’s disease: Can reliable distinctions be observed?
A novel visuomotor (VM) assessment effectively distinguishes Alzheimer’s patients from healthy controls and can be efficiently used in primary healthcare settings.
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Research Paper
Transcranial Magnetic Stimulation Over Human Dorsal–Lateral Posterior Parietal Cortex Disrupts Integration of Hand Position Signals Into the Reach Plan
TMS over dorsal–lateral PPC disrupts the integration of hand position into the reach plan, but visual feedback can recalibrate the perturbed signal.
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Research Paper
Blast in Context: The Neuropsychological and Neurocognitive Effects of Long-Term Occupational Exposure to Repeated Low-Level Explosives on Canadian Armed Forces’ Breaching Instructors and Range Staff
Breaching, concussion history, and deployment in military personnel are linked to post-concussive symptoms, reduced energy, and cognitive-motor deficits.
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Research Paper
Hemispheric Asymmetry in Memory-Guided Pointing During Single-Pulse Transcranial Magnetic Stimulation of Human Parietal Cortex
Left parietal TMS increases pointing variability, while right parietal TMS causes a leftward shift, indicating motor-coordinate processing.
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Research Paper
The time course for kinetic versus kinematic planning of goal-directed human motor behavior
This study finds that motor planning initially uses a coarse approximation of limb dynamics, refining the plan as the movement progresses.
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Research Paper
Visuomotor impairments in older adults at increased Alzheimer's disease risk
Research examining cognitive-motor integration deficits in older adults at heightened risk for Alzheimer's disease.
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Clinical Research
Visuomotor integration is impaired in early stage Alzheimer's disease
Study demonstrating impaired visuomotor coordination in patients with early-stage Alzheimer's disease.
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Neuroscience Study
Extensive video-game experience alters cortical networks for complex visuomotor transformations
Investigation of how video game experience modifies brain networks involved in complex cognitive-motor tasks.
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Research Paper
Adults at Increased Alzheimer's Risk Display Cognitive-Motor Integration Impairment
Analysis of cognitive-motor integration deficits in adults with elevated Alzheimer's disease risk factors.
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Neuroimaging Study
Cortical BOLD fMRI Activity During Increasingly Complex Visually Guided Movements
fMRI study revealing brain activation patterns during progressively complex visuomotor coordination tasks.
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Sports Medicine
The Effects of Concussion History on Cognitive-Motor Integration in Elite-Level Athletes
Research on how concussion history impacts cognitive-motor performance in professional athletes.
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Neuroscience Study
Brain Mechanisms for Preparing Increasingly Complex Sensory to Motor Transformations
Study examining neural mechanisms underlying preparation for complex sensory-motor integration tasks..
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Sports Medicine
Cognitive-Motor Integration Deficits in Young Athletes Following Concussion
Investigation of cognitive-motor impairments in youth athletes after concussion injuries.
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Clinical Research
Cognitive-Motor Integration in Adults with Mild Cognitive Impairment
Research on cognitive-motor coordination deficits in adults diagnosed with mild cognitive impairment.
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